I had to send my phone in for repair again, so once again I was looking at backing it up over the weekend.
I have the HTC Sync\Backup app installed but it does not seem to offer that much in terms of app backup.
Via Lifehacker I took a look at Helium desktop which is advertised as working without rooting your phone. I installed the windows app & the android app. Even though I can see the contents off my phone in windows explorer and in htc sync manager when I connect it, Helium did not see my phone asking me to install drivers.
Following the Helium installation instructions I installed the common HTC driver listed and restarted but I still got the error message.
So no change at the moment to my backup process.